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Phase II Study of Intensive Chemotherapy With Autologous Peripheral Blood Stem Cell Support in Patients With Cisplatin Resistant Germ Cell Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow patients to tolerate higher doses of chemotherapy and kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy and peripheral stem cell transplantation in treating patients who have germ cell tumors that have not responded to previous chemotherapy.
Details
| Lead sponsor | UNICANCER |
|---|---|
| Phase | Phase 2 |
| Status | TERMINATED |
| Enrolment | 45 |
| Start date | 1998-03 |
| Completion | 2000-03 |
Conditions
- Childhood Germ Cell Tumor
- Extragonadal Germ Cell Tumor
- Ovarian Cancer
- Testicular Germ Cell Tumor
Interventions
- filgrastim
- carboplatin
- cyclophosphamide
- epirubicin hydrochloride
- etoposide
- ifosfamide
- paclitaxel
- thiotepa
- bone marrow ablation with stem cell support
- peripheral blood stem cell transplantation
Countries
France