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The Value of Dexamethasone Versus Prednisolone During Induction and Maintenance Therapy of Prolonged Versus Conventional Duration of L-Asparaginase Therapy During Consolidation and Late Intensification, and of Corticosteroid + VCR Pulses During Maintenance in Acute Lymphoblastic Leukemia and Lymphoblastic Non-Hodgkin Lymphoma of Childhood
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which regimen of combination chemotherapy plus steroid therapy is more effective for acute lymphoblastic leukemia or lymphoblastic non-Hodgkin's lymphoma. PURPOSE: Randomized phase III trial to compare the effectiveness of different regimens of combination chemotherapy plus steroid therapy in treating children who have acute lymphoblastic leukemia or lymphoblastic non-Hodgkin's lymphoma.
Details
| Lead sponsor | European Organisation for Research and Treatment of Cancer - EORTC |
|---|---|
| Phase | Phase 3 |
| Status | UNKNOWN |
| Enrolment | 1500 |
| Start date | 1998-12 |
Conditions
- Leukemia
- Lymphoma
Interventions
- asparaginase
- cyclophosphamide
- cytarabine
- daunorubicin hydrochloride
- dexamethasone
- doxorubicin hydrochloride
- etoposide
- leucovorin calcium
- mercaptopurine
- methotrexate
Primary outcomes
- Event-free survival after first randomization
- Disease-free survival after second and third randomization
Countries
Belgium, France, Portugal