Last reviewed · How we verify
NCT00003684
Theophylline in Treating Cancer Patients With Shortness of Breath
Phase 3 trial testing theophylline in Pulmonary Complications in 3 participants. Completed in 15 December 2008.
15 December 2008
Quick facts
| Lead sponsor | NCIC Clinical Trials Group |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | supportive care |
| Enrollment | 3 |
| Start date | 24 March 1998 |
| Primary completion | 15 December 2008 |
| Estimated completion | 15 December 2008 |
| Sites | 4 locations across Canada |
Drugs / interventions tested
- theophylline — full drug profile →
- quality-of-life assessment
Conditions studied
- Pulmonary Complications — all drugs for Pulmonary Complications →
- Quality of Life — all drugs for Quality of Life →
- Unspecified Adult Solid Tumor, Protocol Specific — all drugs for Unspecified Adult Solid Tumor, Protocol Specific →
Sponsor
NCIC Clinical Trials Group
Who can join
Adults 16 to 120, any sex, with Pulmonary Complications or Quality of Life. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
RATIONALE: Theophylline may help to relieve shortness of breath in patients who have cancer. It is not yet known whether theophylline is more effective than no further treatment for shortness of breath. PURPOSE: Randomized phase III trial to determine the effectiveness of theophylline in treating shortness of breath in patients who have cancer.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy.
Lawless MW, O'Byrne KJ, Gray SG. · · 2009 · cited 69× · PMID 19602054 · DOI 10.1111/j.1582-4934.2009.00845.x
Verify or expand the search:
- PubMed search for NCT00003684
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of theophylline
Trials testing the same drug.
- NCT05947643 — Smell in COVID-19 and Efficacy of Nasal Theophylline (SCENT 3) · Phase 2 · completed
Other recruiting trials for Pulmonary Complications
Currently open trials in the same condition.
- NCT06608849 — The Incidence of Pulmonary, Cardiovascular and Renal System Non-communicable Complications Associated With the Post-acut · recruiting
- NCT07192575 — Prevention of Pulmonary Complications After Laparoscopic Liver Surgery · NA · recruiting
Other NCIC Clinical Trials Group trials
Trials by the same sponsor.
- NCT01916187 — Imetelstat Given Intravenously Alone and With Standard 13-Cis-Retinoic Acid in Children With Neuroblastoma · Phase 1 · withdrawn
- NCT01830621 — BBI608 and Best Supportive Care vs Placebo and Best Supportive Care in Pretreated Advanced Colorectal Carcinoma · Phase 3 · completed
- NCT01652144 — A Phase II Study of AT7519M, a CDK Inhibitor, in Patients With Relapsed Mantle Cell Lymphoma · Phase 2 · completed
- NCT01627054 — A Phase II Study of AT7519M, a CDK Inhibitor, in Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia · Phase 2 · completed
- NCT01486368 — A Phase II Study of PF-03446962 in Patients With Advanced Malignant Pleural Mesothelioma · Phase 2 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00003684 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by NCIC Clinical Trials Group
- Last refreshed: 3 April 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00003684.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing