Phase I/II Trial of Sequential Doxorubicin/Gemcitabine (AG) and Ifosfamide, Paclitaxel, and Cisplatin (ITP) Chemotherapy (AG-ITP) in Patients With Metastatic or Locally Advanced Transitional Cell Carcinoma of the Urothelium

NCT00003105 Phase 1/Phase 2 COMPLETED

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase I/II trial to study the effectiveness of combination chemotherapy in treating patients with metastatic or locally advanced bladder cancer.

Details

Lead sponsor	Memorial Sloan Kettering Cancer Center
Phase	Phase 1/Phase 2
Status	COMPLETED
Enrolment	30
Start date	1997-09
Completion	2004-08

Conditions

• Bladder Cancer
• Transitional Cell Cancer of the Renal Pelvis and Ureter

Interventions

• filgrastim
• cisplatin
• doxorubicin hydrochloride
• gemcitabine hydrochloride
• ifosfamide
• paclitaxel

Countries

United States