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Phase III Randomized Trial of Autologous and Allogeneic Stem Cell Transplantation Versus Intensive Conventional Chemotherapy in Acute Lymphoblastic Leukemia in First Remission
RATIONALE: Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with allogeneic or autologous stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. It is not yet known whether stem cell transplantation is more effective than standard chemotherapy in treating acute lymphoblastic leukemia. PURPOSE: This randomized phase III trial is studying how well stem cell transplantation works compared to standard combination chemotherapy in treating patients with acute lymphoblastic leukemia in first remission.
Details
| Lead sponsor | Eastern Cooperative Oncology Group |
|---|---|
| Phase | Phase 3 |
| Status | COMPLETED |
| Enrolment | 1929 |
| Start date | 1993-05-07 |
Conditions
- Leukemia
Interventions
- sargramostim
- asparaginase
- cyclophosphamide
- cytarabine
- daunorubicin hydrochloride
- dexamethasone
- etoposide
- imatinib mesylate
- leucovorin calcium
- mercaptopurine
Primary outcomes
- Overall Survival — All patients were followed for 2 years
Countries
United States