NCT00002019

Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome

Completed NA Last updated 23 June 2005

What this trial tests

NA trial testing Amphotericin B, Lipid-based in Meningitis, Cryptococcal. Completed.

Quick facts

Lead sponsor	Liposome
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Primary purpose	treatment
Sites	19 locations across United States

Drugs / interventions tested

• Amphotericin B, Lipid-based — full drug profile →
• Amphotericin B (AMPHOTERICIN B) — full drug profile →

Conditions studied

• Meningitis, Cryptococcal — all drugs for Meningitis, Cryptococcal →
• HIV Infections — all drugs for HIV Infections →

Sponsor

Liposome — full company profile →

Who can join

18 and older, any sex, with Meningitis, Cryptococcal or HIV Infections. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To evaluate the safety, tolerance and efficacy of three different dosage regimens of Amphotericin B Lipid Complex (ABLC) compared to Fungizone (Amphotericin B) in patients with AIDS and cryptococcal meningitis.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

1. Amphotericin B deoxycholate versus liposomal amphotericin B: effects on kidney function.
   Botero Aguirre JP, Restrepo Hamid AM. · · 2015 · cited 56× · PMID 26595825 · DOI 10.1002/14651858.cd010481.pub2
2. "Decision for adjuvant treatment in stage II colon cancer based on circulating tumor DNA:The CIRCULATE-PRODIGE 70 trial".
   Taïeb J, Benhaim L, Laurent Puig P, Le Malicot K, et al · · 2020 · cited 31× · PMID 32482534 · DOI 10.1016/j.dld.2020.04.010
3. Liquid Biopsy and Challenge of Assay Heterogeneity for Minimal Residual Disease Assessment in Colon Cancer Treatment.
   Crisafulli G. · · 2025 · cited 8× · PMID 39858618 · DOI 10.3390/genes16010071
4. From Early Detection To Advanced Therapies: How Circulating Tumor DNA Is Transforming the Care of Colorectal Cancer.
   Yee EJ, McCarter MD, Vogel JD, Schulick RD, et al · · 2025 · cited 1× · PMID 41182655 · DOI 10.1007/s11912-025-01725-8
5. Inorganic Nanoparticles: Tools to Emphasize the Janus Face of Amphotericin B.
   Boudier A, Mammari N, Lamouroux E, Duval RE. · · 2023 · cited 1× · PMID 37887244 · DOI 10.3390/antibiotics12101543
6. Microencapsulation Techniques in HIV Pediatric Formulations: Advances and Future Outlook.
   Okafor NI. · · 2024 · PMID 39421019 · DOI 10.1155/2024/5081655