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NCT00001620

Screening for Hematology Branch Protocols

ENROLLING BY INVITATION Last updated 8 April 2026
What this trial tests

trial in Hematologic Disease and Disorders in 10,000 participants. Enrolling by invitation.

Timeline
31 December 1996

Quick facts

Lead sponsorNational Heart, Lung, and Blood Institute (NHLBI)
StatusENROLLING BY INVITATION
Study typeOBSERVATIONAL
Enrollment10,000
Start date31 December 1996
Sites1 location across United States

Conditions studied

Sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Who can join

Adults 2 to 100, any sex, with Hematologic Disease and Disorders or Donors. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study allows the evaluation of subjects in order to determine their ability to safely participate in other active research studies. After subjects complete the screening process, they will be offered the opportunity to participate in an active research study, or if no appropriate studies are available information and recommendations will be provided for other treatment options....

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells.
    Zhao X, Zhao X, Gao S, Wu Z, et al · · 2017 · cited 52× · PMID 29030335 · DOI 10.1182/blood-2017-08-803353
  2. Early activation of inflammatory pathways in UBA1-mutated hematopoietic stem and progenitor cells in VEXAS.
    Wu Z, Gao S, Gao Q, Patel BA, et al · · 2023 · cited 49× · PMID 37586319 · DOI 10.1016/j.xcrm.2023.101160
  3. The Spectrum of Hepatic Involvement in Patients With Telomere Disease.
    Kapuria D, Ben-Yakov G, Ortolano R, Cho MH, et al · · 2019 · cited 47× · PMID 30791107 · DOI 10.1002/hep.30578
  4. Circulating S100A8 and S100A9 protein levels in plasma of patients with acquired aplastic anemia and myelodysplastic syndromes.
    Giudice V, Wu Z, Kajigaya S, Fernandez Ibanez MDP, et al · · 2019 · cited 37× · PMID 29958797 · DOI 10.1016/j.cyto.2018.06.025
  5. Sequencing of RNA in single cells reveals a distinct transcriptome signature of hematopoiesis in GATA2 deficiency.
    Wu Z, Gao S, Diamond C, Kajigaya S, et al · · 2020 · cited 33× · PMID 32556286 · DOI 10.1182/bloodadvances.2019001352
  6. Long noncoding RNAs of single hematopoietic stem and progenitor cells in healthy and dysplastic human bone marrow.
    Wu Z, Gao S, Zhao X, Chen J, et al · · 2019 · cited 30× · PMID 30545929 · DOI 10.3324/haematol.2018.208926
  7. Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders.
    Balakumaran A, Mishra PJ, Pawelczyk E, Yoshizawa S, et al · · 2015 · cited 27× · PMID 25499762 · DOI 10.1182/blood-2014-06-566810
  8. Differential diagnosis of bone marrow failure syndromes guided by machine learning.
    Gutierrez-Rodrigues F, Munger E, Ma X, Groarke EM, et al · · 2023 · cited 23× · PMID 36542832 · DOI 10.1182/blood.2022017518

Verify or expand the search:

Other recruiting trials for Hematologic Disease and Disorders

Currently open trials in the same condition.

Other National Heart, Lung, and Blood Institute (NHLBI) trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00001620.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing