Study of Protease Inhibitor and/or Non-Nucleoside Reverse Transcriptase Inhibitor With Dual Nucleosides in Initial Therapy of HIV Infection

NCT00000919 NA COMPLETED

The purpose of this study is to compare the effectiveness of various combinations of anti-HIV drugs in HIV-positive men and women. Patients receive specific combinations of 3 or 4 of the following 6 drugs: didanosine (ddI), stavudine (d4T) efavirenz (EFV), nelfinavir (NFV), lamivudine (3TC), or zidovudine (ZDV). Anti-HIV therapy is effective in preventing the spread of HIV in the body. However, patients often experience unpleasant side effects and have difficulties following the dosing schedule. This study looks for combinations of anti-HIV drugs ("cocktails") which will be the most effective with the fewest problems.

Details

Lead sponsor	National Institute of Allergy and Infectious Diseases (NIAID)
Phase	NA
Status	COMPLETED
Enrolment	900
Completion	2002-11

Conditions

• HIV Infections

Interventions

• Indinavir sulfate
• Lamivudine/Zidovudine
• Ritonavir
• Hydroxyurea
• Abacavir sulfate
• Amprenavir
• Nelfinavir mesylate
• Efavirenz
• Lamivudine
• Stavudine

Countries

United States, Italy, Puerto Rico