Voltage-gated calcium channel alpha-2-delta subunit — Drug Target

All drugs that target Voltage-gated calcium channel alpha-2-delta subunit — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

Anticonvulsant; gabapentinoid · Gabapentinoid; anticonvulsant/neuropathic pain agent · Gabapentinoid; anticonvulsant; analgesic

Marketed (2)

• Gabapentin immediate release · Theresa Zesiewicz, MD · Anticonvulsant; gabapentinoid · Neurology
  Gabapentin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters.
• Gabapentin Enacarbil (GEn) · Cleveland Sleep Research Center · Gabapentinoid; anticonvulsant/neuropathic pain agent · Neurology
  Gabapentin enacarbil is a prodrug of gabapentin that enhances GABA neurotransmission in the central nervous system by increasing inhibitory signaling.

Phase 3 pipeline (1)

• Lyrica (low dose) · KunWha Pharmaceutical Co., Ltd. · Gabapentinoid; anticonvulsant; analgesic · Neurology; Pain Management
  Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters.