TREM2 — Drug Target

2 drugs 1 marketed 1 in Phase 3

All drugs that target TREM2 — marketed and clinical-stage. Includes 2 drug classes acting on this target.

Drug classes

TREM2 activator monoclonal antibody · TREM2 agonist monoclonal antibody

Marketed (1)

AL003 · Alector Inc. · TREM2 activator monoclonal antibody · Neurology
AL003 is a monoclonal antibody that activates TREM2 signaling on microglia to promote neuroinflammatory resolution and clearance of pathogenic proteins in the central nervous system.

Phase 3 pipeline (1)

AL001 · Alector Inc. · TREM2 agonist monoclonal antibody · Neurology
AL001 is a monoclonal antibody that activates TREM2 signaling on microglia to promote neuroinflammatory resolution and clearance of pathogenic proteins in neurodegenerative disease.