Topoisomerase I and DNA — Drug Target

All drugs that target Topoisomerase I and DNA — marketed and clinical-stage. Includes 1 drug classes acting on this target.

Drug classes

Topoisomerase inhibitor and platinum-based chemotherapy

Phase 3 pipeline (1)

• combination of irinotecan and cisplatin · Japan Clinical Oncology Group · Topoisomerase inhibitor and platinum-based chemotherapy · Oncology
  Irinotecan inhibits topoisomerase I, while cisplatin induces DNA crosslinks, both mechanisms leading to cell death in rapidly dividing cancer cells.