Smoothened — Drug Target

All drugs that target Smoothened — marketed and clinical-stage. Includes 1 drug classes acting on this target.

Drug classes

Hedgehog Pathway Inhibitor [EPC]

Marketed (2)

• Erivedge · Roche · Hedgehog Pathway Inhibitor [EPC] · Oncology
  Vismodegib inhibits the Hedgehog pathway by binding to and blocking Smoothened, a key protein in the pathway.
• SONIDEGIB
  Sonidegib inhibits the Hh pathway by binding to and blocking Smoothened, a key transmembrane protein.