Renin — Drug Target

All drugs that target Renin — marketed and clinical-stage. Includes 6 drug classes acting on this target.

Drug classes

Thiazide Diuretic [EPC] · direct renin inhibitor · Renin Inhibitor · Direct renin inhibitor · remikiren · Renin inhibitor

Marketed (3)

• Capozide 25/15 · Aarxion Anda Hlding · Thiazide Diuretic [EPC] · Metabolic
• Keverprazan 14 days · Second Affiliated Hospital, School of Medicine, Zhejiang University · direct renin inhibitor · Cardiovascular
  Keverprazan is a direct renin inhibitor.
• Tekturna · Lxo Ireland · Renin Inhibitor · Cardiovascular
  Tekturna works by blocking the renin enzyme, which is involved in the production of angiotensin II, a potent vasoconstrictor.

Phase 3 pipeline (1)

• Aliskiren 150 · Novartis · Direct renin inhibitor · Cardiovascular
  Aliskiren is a direct renin inhibitor that blocks the first step of the renin-angiotensin-aldosterone system (RAAS) by preventing renin from converting angiotensinogen to angiotensin I.

Phase 2 pipeline (2)

• Ro 42-5892 · remikiren · Cardiovascular
  Remikiren works by directly inhibiting the renin enzyme, which plays a key role in the renin-angiotensin-aldosterone system (RAAS) that regulates blood pressure.
• Direct renin inhibitor · Medical Practice Prof D. Ivanov · Direct renin inhibitor · Cardiovascular
  A direct renin inhibitor blocks the enzyme renin, preventing the initial step of the renin-angiotensin-aldosterone system (RAAS) and reducing blood pressure.

Phase 1 pipeline (1)

• Aliskiren 3.125 mini-tablets · Novartis · Renin inhibitor · Cardiovascular
  Aliskiren is a direct renin inhibitor that blocks the conversion of angiotensinogen to angiotensin I, reducing blood pressure.