NK1 receptor — Drug Target

All drugs that target NK1 receptor — marketed and clinical-stage. Includes 2 drug classes acting on this target.

Drug classes

Neurokinin-1 (NK1) receptor antagonist · NK1 receptor antagonist

Phase 3 pipeline (9)

• Comparator: MK0517 · Merck Sharp & Dohme LLC · Neurokinin-1 (NK1) receptor antagonist · Oncology; Gastroenterology
  MK0517 is a selective antagonist of the neurokinin-1 (NK1) receptor that blocks substance P signaling in the central nervous system.
• Comparator: Placebo to aprepitant · Merck Sharp & Dohme LLC · Neurokinin-1 (NK1) receptor antagonist · Oncology
  Aprepitant is a neurokinin-1 (NK1) receptor antagonist that blocks substance P signaling in the chemoreceptor trigger zone and vomiting center to prevent chemotherapy-induced nausea and vomiting.
• Vehicle to AGN-199201 · Allergan · Neurokinin-1 (NK1) receptor antagonist · Pain Management / Neurology
  AGN-199201 is a selective antagonist of the neurokinin-1 (NK1) receptor that modulates pain signaling in the central nervous system.
• saredutant (SR48968) · Sanofi · NK1 receptor antagonist · Oncology
  Saredutant is an antagonist of the neurokinin-1 (NK1) receptor.
• MK0954, /Duration of Treatment : 5 Years · Organon and Co · Neurokinin-1 (NK1) receptor antagonist · Oncology; Pain Management
  MK0954 is a selective antagonist of the neurokinin-1 (NK1) receptor that blocks substance P signaling in the central nervous system.
• MK0954, /Duration of Treatment : 16 Weeks · Organon and Co · Neurokinin-1 (NK1) receptor antagonist · Pain management / Neurology
  MK0954 is a selective antagonist of the neurokinin-1 (NK1) receptor that blocks substance P signaling in the central nervous system.
• placebo to aprepitant · Merck Sharp & Dohme LLC · NK1 receptor antagonist · Oncology
  Aprepitant is a substance P/neurokinin 1 (NK1) receptor antagonist.
• Comparator: Aprepitant · Merck Sharp & Dohme LLC · Neurokinin-1 (NK1) receptor antagonist · Oncology
  Aprepitant is a neurokinin-1 (NK1) receptor antagonist that blocks substance P signaling in the chemoreceptor trigger zone and vomiting center to prevent nausea and vomiting.
• Standard: Aprepitant · CCTU · NK1 receptor antagonist · Oncology
  Aprepitant is a substance P/neurokinin 1 (NK1) receptor antagonist.

Phase 2 pipeline (1)

• Aprepitant vs. Gabapentin · New Mexico Cancer Research Alliance · NK1 receptor antagonist · Oncology
  Aprepitant is a substance P/neurokinin 1 (NK1) receptor antagonist, which blocks the action of substance P, a natural substance in the body that causes nausea and vomiting.