HIV integrase — Drug Target
All drugs that target HIV integrase — marketed and clinical-stage. Includes 5 drug classes acting on this target.
Drug classes
HIV integrase strand transfer inhibitor (INSTI) · Integrase strand transfer inhibitor (INSTI) · Integrase inhibitor · NRTI + INSTI · HIV integrase strand transfer inhibitor
Marketed (12)
- GI265235 · ViiV Healthcare · HIV integrase strand transfer inhibitor (INSTI) · Infectious Disease
GI265235 is an HIV integrase strand transfer inhibitor that prevents HIV from integrating its genetic material into host cell DNA. - Long-acting Cabotegravir injection · MU-JHU CARE · Integrase strand transfer inhibitor (INSTI) · Infectious Disease / Virology
Cabotegravir is an integrase strand transfer inhibitor (INSTI) that blocks HIV integrase, preventing the virus from inserting its genetic material into human DNA. - raltegravir (RAL) · Abbott · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
Raltegravir inhibits HIV integrase, preventing the virus from integrating its genetic material into the host cell's DNA. - Integrase Inhibitor · McGill University Health Centre/Research Institute of the McGill University Health Centre · Integrase inhibitor · Infectious Disease
Integrase inhibitors block HIV integrase, preventing the virus from inserting its genetic material into the host cell's DNA. - cabotegravir, CAB · ViiV Healthcare · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
Cabotegravir is an integrase strand transfer inhibitor (INSTI) that blocks HIV integrase, preventing the virus from inserting its genetic material into human host cell DNA. - Cabotegravir OLI · ViiV Healthcare · Integrase strand transfer inhibitor (INSTI) · Infectious Disease / Virology
Cabotegravir is an integrase strand transfer inhibitor (INSTI) that blocks HIV integrase, preventing the virus from inserting its genetic material into human host cell DNA. - Dolutegravir (DTG) · ViiV Healthcare · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
Dolutegravir inhibits HIV integrase, preventing the virus from inserting its genetic material into the host cell's DNA. - Cabotegravir Injectable Suspension · ViiV Healthcare · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
Cabotegravir is an integrase strand transfer inhibitor that blocks HIV integrase, preventing the virus from inserting its genetic material into human DNA. - Integrase strand transfer inhibitors · Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
Integrase strand transfer inhibitors block HIV integrase, preventing the virus from inserting its genetic material into the host cell's DNA. - APRETUDE (cabotegravir) · Massachusetts General Hospital · Integrase strand transfer inhibitor (INSTI) · Infectious Disease / Virology
Cabotegravir is an integrase strand transfer inhibitor (INSTI) that blocks HIV integrase, preventing the virus from inserting its genetic material into human DNA. - Bictegravir (BIC) · National Institute of Allergy and Infectious Diseases (NIAID) · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
Bictegravir inhibits HIV integrase, preventing the virus from inserting its genetic material into human host cell DNA. - Salvage antiretroviral therapy including raltegravir · Germans Trias i Pujol Hospital · Integrase strand transfer inhibitor (INSTI) · Infectious Disease / Virology
Raltegravir inhibits HIV integrase, preventing the virus from integrating its genetic material into the host cell's DNA.
Phase 3 pipeline (21)
- Dolutegravir film-coated dispersible tablets · ViiV Healthcare · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
Dolutegravir inhibits HIV integrase, preventing the virus from integrating its genetic material into the host cell's DNA. - Cabotegravir (CAB) tablet · National Institute of Allergy and Infectious Diseases (NIAID) · Integrase strand transfer inhibitor (INSTI) · Infectious Disease / Virology
Cabotegravir is an integrase strand transfer inhibitor (INSTI) that blocks HIV integrase, preventing the virus from inserting its genetic material into human host cell DNA. - Dolutegravir Sodium Monohydrate · University of Colorado, Denver · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
Dolutegravir sodium monohydrate inhibits HIV integrase, preventing the virus from integrating its genetic material into the host cell's DNA. - Tenofovir + lamivudine + raltegravir · ANRS, Emerging Infectious Diseases · NRTI + INSTI · Infectious Diseases
Tenofovir and lamivudine are nucleoside reverse transcriptase inhibitors (NRTIs) that block HIV replication by inhibiting viral DNA synthesis. Raltegravir is an integrase strand transfer inhibitor (INSTI) that blocks HIV replication by inhibiting viral integration into the host genome. - Placebo to Reformulated Raltegravir · Merck Sharp & Dohme LLC · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
Raltegravir is an integrase strand transfer inhibitor that blocks HIV integrase, preventing the virus from inserting its genetic material into the host cell's DNA. - CAB LA · National Institute of Allergy and Infectious Diseases (NIAID) · Integrase strand transfer inhibitor (INSTI) · Immunology / Infectious Disease
CAB LA is a long-acting injectable formulation of cabotegravir, an integrase strand transfer inhibitor (INSTI) that blocks HIV integration into host cell DNA. - Comparator: Placebo to MK-0518 · Merck Sharp & Dohme LLC · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
MK-0518 is an integrase strand transfer inhibitor that blocks HIV integrase, preventing the virus from inserting its genetic material into human DNA. - CAB-LA Maintenance Dose · National Institute of Allergy and Infectious Diseases (NIAID) · Integrase strand transfer inhibitor (INSTI) · Immunology / Infectious Disease
CAB-LA is a long-acting injectable formulation of cabotegravir, an integrase strand transfer inhibitor (INSTI) that blocks HIV integrase to prevent viral replication. - Cabotegravir Tablets, for oral use. · ANRS, Emerging Infectious Diseases · Integrase strand transfer inhibitor (INSTI) · Infectious Disease / Virology
Cabotegravir is an integrase strand transfer inhibitor (INSTI) that blocks HIV integrase, preventing the virus from inserting its genetic material into human host cell DNA. - RPV OLI · ViiV Healthcare · HIV integrase strand transfer inhibitor · Infectious Disease
RPV OLI is a HIV integrase strand transfer inhibitor. - DTG · ViiV Healthcare · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
DTG (dolutegravir) is an integrase strand transfer inhibitor that blocks HIV integrase, preventing the virus from inserting its genetic material into human DNA. - Placebo to Raltegravir · Merck Sharp & Dohme LLC · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
Raltegravir is an integrase strand transfer inhibitor that blocks HIV integrase, preventing the virus from inserting its genetic material into the host cell's DNA. - raltegravir (Isentress) · Groupe d'Etude sur le Risque d'Exposition des Soignants aux Agents Infectieux · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
Raltegravir inhibits HIV integrase, preventing the virus from integrating its genetic material into the host cell's DNA. - Dolutegravir film-coated tablets · ViiV Healthcare · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
Dolutegravir inhibits HIV integrase, preventing the virus from integrating its genetic material into the host cell's DNA. - GSK1349572 (dolutegravir) · ViiV Healthcare · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
Dolutegravir inhibits HIV integrase, preventing the virus from inserting its genetic material into human DNA. - Cabotegravir (CAB) LA · Desmond Tutu HIV Foundation · Integrase strand transfer inhibitor (INSTI) · Infectious Disease / Virology
Cabotegravir is an integrase strand transfer inhibitor (INSTI) that blocks HIV integrase, preventing the virus from inserting its genetic material into human DNA. - Cabotegravir Tablets · ViiV Healthcare · Integrase strand transfer inhibitor (INSTI) · Infectious Disease / Virology
Cabotegravir is an integrase strand transfer inhibitor (INSTI) that blocks HIV integrase, preventing the virus from inserting its genetic material into human DNA. - Reformulated Raltegravir · Merck Sharp & Dohme LLC · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
Reformulated raltegravir is an integrase strand transfer inhibitor that prevents HIV from integrating its genetic material into the host cell's DNA. - Oral CAB · ViiV Healthcare · Integrase strand transfer inhibitor (INSTI) · Infectious Disease / Virology
Oral CAB is a capsid assembly modulator that inhibits HIV capsid formation, preventing viral replication by disrupting the structural integrity of newly formed HIV particles. - CAB-LA Loading Dose · National Institute of Allergy and Infectious Diseases (NIAID) · Integrase strand transfer inhibitor (INSTI) · Immunology / Infectious Disease
CAB-LA is a long-acting injectable formulation of cabotegravir, an integrase strand transfer inhibitor (INSTI) that blocks HIV integrase to prevent viral replication. - MK-0518 · Merck Sharp & Dohme LLC · Integrase strand transfer inhibitor (INSTI) · Infectious Disease
MK-0518 is an integrase strand transfer inhibitor that blocks HIV integrase, preventing the virus from inserting its genetic material into human host cell DNA.
Phase 2 pipeline (2)
- CAB Oral Tablets · ViiV Healthcare · Integrase strand transfer inhibitor (INSTI) · Infectious Disease / Virology
CAB (cabotegravir) is an integrase strand transfer inhibitor that blocks HIV integrase, preventing the virus from inserting its genetic material into host cell DNA. - DTG based ARV regimen without ABC · ViiV Healthcare · Integrase strand transfer inhibitor (INSTI) · Infectious Disease / Virology
DTG (dolutegravir) is an integrase strand transfer inhibitor that blocks HIV integrase, preventing the virus from inserting its genetic material into host cell DNA.