Gonadotropin-releasing hormone receptor — Drug Target

All drugs that target Gonadotropin-releasing hormone receptor — marketed and clinical-stage. Includes 8 drug classes acting on this target.

Drug classes

Gonadotropin Releasing Hormone Receptor Antagonist · Gonadotropin Releasing Hormone Receptor Antagonist [EPC] · Gonadotropin Releasing Hormone Receptor Agonist · gonadorelin · leuprorelin · abarelix · buserelin · Releasing hormone agonist

Marketed (18)

• Orilissa · AbbVie · Gonadotropin Releasing Hormone Receptor Antagonist · Pain
  Orilissa blocks the hormone signals that stimulate the growth of endometrial tissue.
• Orgovyx · MYOVANT SCIENCES · Gonadotropin Releasing Hormone Receptor Antagonist [EPC] · Oncology
  Relugolix is a nonpeptide GnRH receptor antagonist that competitively binds to pituitary GnRH receptors.
• Yselty · Obseva Ireland Ltd · Other
• Cetrotide · Merck KGaA · Gonadotropin Releasing Hormone Receptor Antagonist · Other
• Ganirelix Acetate · Organon Usa Organon · Gonadotropin Releasing Hormone Receptor Antagonist · Other
• Vantas · Gonadotropin Releasing Hormone Receptor Agonist · Oncology
  Vantas works by binding to the gonadotropin-releasing hormone receptor, mimicking the natural hormone and reducing the production of sex hormones.
• Zoladex · Tersera · Gonadotropin Releasing Hormone Receptor Agonist · Oncology
  Zoladex works by mimicking the body's natural hormone to reduce testosterone production.
• Fertagyl · gonadorelin · Other
• Firmagon · Centre Leon Berard · Oncology
• Plenaxis · PRAECIS Pharmaceuticals Inc. · Other
• DESLORELIN · Other
• Lupron · Accord Healthcare S.L.U. · Gonadotropin Releasing Hormone Receptor Agonist · Oncology
  Lupron works by binding to and activating the gonadotropin-releasing hormone receptor, which ultimately leads to a decrease in the production of sex hormones.
• Leuprolide Acetate · Pfizer · leuprorelin · Oncology
  Leuprolide acetate is a manufactured version of a hormone that regulates growth and development, used to treat hormone-related conditions.
• Firmagon · Ferring · Gonadotropin Releasing Hormone Receptor Antagonist · Oncology
  Firmagon works by blocking the action of gonadotropin-releasing hormone on the pituitary gland, which reduces testosterone production.
• Trelstar · Verity · Gonadotropin Releasing Hormone Receptor Agonist · Oncology
  Trelstar works by binding to and activating the gonadotropin-releasing hormone receptor, which leads to a decrease in testosterone production.
• Plenaxis · Speciality European · abarelix · Other
• Synarel · Pfizer · Gonadotropin Releasing Hormone Receptor Agonist · Other
• Receptal · Sanofi K.K. · buserelin · Other

Phase 3 pipeline (1)

• releasing hormone agonist therapy · Cancer Research UK · Releasing hormone agonist · Oncology
  Releasing hormone agonist therapy works by mimicking the action of natural hormones to stimulate the release of other hormones.