What drugs target GABA-B receptor?

5+ drugs target GABA-B receptor, including Lioresal, Sodium Oxybate (SMO), placebo + oral baclofen, Baclofen ER.

GABA-B receptor — Drug Target

5 drugs 4 marketed

All drugs that target GABA-B receptor — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Lioresal · gamma-Aminobutyric Acid-ergic Agonist [EPC] · Neuroscience
Sodium Oxybate (SMO) · Catholic University of the Sacred Heart · GABA-B receptor agonist; CNS depressant · Neurology
Sodium oxybate is a central nervous system depressant that acts as a GABA-B receptor agonist and GHB (gamma-hydroxybutyrate) precursor to promote sleep and reduce excessive daytime sleepiness.
placebo + oral baclofen · Shaare Zedek Medical Center · GABA-B receptor agonist · Neurology
Baclofen is a GABA-B receptor agonist that enhances inhibitory neurotransmission in the central nervous system to reduce muscle spasticity and hyperreflexia.
Baclofen ER · Alkermes, Inc. · GABA-B receptor agonist · Neurology
Baclofen ER is a GABA-B receptor agonist that reduces neuronal excitability and muscle tone by enhancing inhibitory neurotransmission in the central nervous system.