farnesyltransferase — Drug Target

All drugs that target farnesyltransferase — marketed and clinical-stage. Includes 2 drug classes acting on this target.

Drug classes

Farnesyltransferase Inhibitor [EPC] · Farnesyltransferase inhibitor

Marketed (1)

• Zokinvy · Sentynl Theraps Inc · Farnesyltransferase Inhibitor [EPC] · Oncology
  Lonafarnib prevents farnesylation of progerin and similar proteins by inhibiting farnesyltransferase.

Phase 3 pipeline (2)

• Placebo Lonafarnib · Eiger BioPharmaceuticals · Farnesyltransferase inhibitor · Oncology
  Lonafarnib inhibits farnesyltransferase, blocking the post-translational modification of proteins involved in cell proliferation and survival.
• Tipifarnib;Zarnestra; R115777 · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. · Farnesyltransferase inhibitor · Oncology
  Tipifarnib is a farnesyltransferase inhibitor that blocks the farnesylation of Ras proteins, which are involved in cell signaling and proliferation.