5-HT1A receptor — Drug Target

All drugs that target 5-HT1A receptor — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

5-HT1A receptor agonist · 5-HT1A receptor antagonist · Serotonin receptor antagonist

Marketed (2)

• Buspirone HCl · Par Pharmaceutical, Inc. · 5-HT1A receptor agonist · Psychiatry/Neurology
  Buspirone acts as a serotonin 5-HT1A receptor agonist to reduce anxiety without the sedation or dependence associated with benzodiazepines.
• Usual dose treatment of Tandospirone · Sumitomo Pharma (Suzhou) Co., Ltd. · 5-HT1A receptor agonist · Psychiatry/Neurology
  Tandospirone is a serotonin 1A (5-HT1A) receptor agonist that enhances serotonergic neurotransmission in the central nervous system.

Phase 3 pipeline (3)

• URAPIDIL (EUPRESSYL*) · University Hospital, Strasbourg, France · 5-HT1A receptor antagonist · Cardiovascular
  Urapidil is a selective and competitive antagonist of the 5-HT1A receptor.
• SPN-810 (18 mg) · Supernus Pharmaceuticals, Inc. · 5-HT1A receptor agonist · Psychiatry/Neurology
  SPN-810 is a selective serotonin 5-HT1A receptor agonist that modulates serotonergic neurotransmission to reduce impulsivity and improve behavioral control.
• Placebon · Visirna Therapeutics HK Limited · Serotonin receptor antagonist · Psychiatry
  Placebon is a small molecule that targets the serotonin receptor.