3-hydroxy-3-methylglutaryl-coenzyme A reductase — Drug Target

All drugs that target 3-hydroxy-3-methylglutaryl-coenzyme A reductase — marketed and clinical-stage. Includes 4 drug classes acting on this target.

Drug classes

HMG-CoA Reductase Inhibitor · cerivastatin · atorvastatin · meglutol

Marketed (4)

• Livalo · Kowa Co · HMG-CoA Reductase Inhibitor · Metabolic
• Baycol · Bayer · cerivastatin · Metabolic
• Lipitor · Pfizer · atorvastatin · Metabolic
  Lipitor is a selective, competitive inhibitor of HMG-CoA reductase, a key enzyme in cholesterol synthesis.
• Mevacor · Merck & Co. · HMG-CoA Reductase Inhibitor · Metabolic
  Mevacor works by inhibiting the enzyme HMG-CoA reductase, which plays a key role in cholesterol production in the liver.

Phase 2 pipeline (1)

• Mevalon · meglutol · Metabolic
  Mevalon works by blocking an enzyme that helps produce cholesterol in the liver.