US Patent

US8877795 — Identification of stabilizers of multimeric proteins

Formulation · Assigned to Leland Stanford Junior University · Expires 2031-05-05 · 5y remaining

Vulnerability score 61/100 Moderate — design-around opportunities exist

What this patent protects

This patent protects methods and compounds for increasing the stability of a protein called TTR tetramer and reducing its tendency to form aggregates.

USPTO Abstract

Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of TTR and thereby decreasing aggregate formation by TTR. Also disclosed herein are methods to screen for candidate compounds that increase stability of TTR. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein.

Drugs covered by this patent

Patent Metadata

Patent number
US8877795
Jurisdiction
US
Classification
Formulation
Expires
2031-05-05
Drug substance claim
No
Drug product claim
Yes
Assignee
Leland Stanford Junior University
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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