US Patent

US8871273 — Method for producing granules

Formulation · Assigned to Takeda Pharmaceutical Co Ltd · Expires 2028-01-11 · 2y remaining

Vulnerability score 60/100 Moderate — design-around opportunities exist

What this patent protects

This patent protects a method for producing granules containing a biologically active substance by heating them to a certain temperature.

USPTO Abstract

In a production process of granules containing a biologically active substance, variation in the elution profile of the biologically active substance is reduced by heating the temperature of granules to about 50° C. or higher and maintaining the temperature for about 1 minute or longer. By setting the spray speed to about 90 mg/min or more per 1 g of cores when a spray agent for a primary agent containing the biologically active substance is sprayed while spraying a binding liquid to the cores and setting the total feeding weight per unit area for a centrifugal fluidized bed coating granulation machine to about 1.5 g/cm 2 or more, the variation in the elution profile of the biologically active substance from the granules is reduced.

Drugs covered by this patent

Patent Metadata

Patent number
US8871273
Jurisdiction
US
Classification
Formulation
Expires
2028-01-11
Drug substance claim
No
Drug product claim
Yes
Assignee
Takeda Pharmaceutical Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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