US Patent

US8664239 — Tacrolimus for improved treatment of transplant patients

Method of Use · Assigned to Veloxis Pharmaceuticals AS · Expires 2028-08-30 · 2y remaining

Vulnerability score 75/100 Vulnerable — likely target for IPR or design-around

What this patent protects

This patent protects an extended release oral dosage form of tacrolimus for once daily immunosuppressive treatment of transplant patients.

USPTO Abstract

An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

Drugs covered by this patent

FDA Patent Use Codes

When a patent is method-of-use, FDA lists it once per applicable indication ("U-code"). Each U-code carves out a specific therapeutic use that generic filers must either license or design around.

CodeDescriptionDrug
U-1752 — Prograf
U-1752 — Prograf
U-1752 — Prograf

Patent Metadata

Patent number
US8664239
Jurisdiction
US
Classification
Method of Use
Expires
2028-08-30
Drug substance claim
No
Drug product claim
No
Assignee
Veloxis Pharmaceuticals AS
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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