US Patent

US8658678 — Methods and compositions for increasing solubility of azole drug compounds that are poorly soluble in water

Method of Use · Assigned to Dow Pharmaceutical Sciences Inc · Expires 2028-06-27 · 2y remaining

Vulnerability score 75/100 Vulnerable — likely target for IPR or design-around

What this patent protects

This patent protects methods and compositions that increase the solubility of poorly soluble azole drug compounds, such as metronidazole, in water.

USPTO Abstract

The combination of any two of a polyol, a polyol ether, and a low carbon organic alcohol provides a synergistic effect on the solubility of azole compounds, such as metronidazole, in aqueous fluid.

Drugs covered by this patent

Metro I.V. In Plastic Container (METRONIDAZOLE) · Baxter

FDA Patent Use Codes

When a patent is method-of-use, FDA lists it once per applicable indication ("U-code"). Each U-code carves out a specific therapeutic use that generic filers must either license or design around.

Code	Description	Drug
`U-1682`	—	Metro I.V. In Plastic Container

Patent Metadata

Patent number: US8658678
Jurisdiction: US
Classification: Method of Use
Expires: 2028-06-27
Drug substance claim: No
Drug product claim: No
Assignee: Dow Pharmaceutical Sciences Inc
Source: FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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