US Patent

US8354427 — Modulators of ATP-binding cassette transporters

Method of Use · Assigned to Vertex Pharmaceuticals Inc · Expires 2026-07-06 · 0y remaining

Vulnerability score 88/100 Vulnerable — likely target for IPR or design-around

What this patent protects

This patent protects modulators of ATP-Binding Cassette transporters and methods for treating diseases mediated by these transporters.

USPTO Abstract

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Drugs covered by this patent

FDA Patent Use Codes

When a patent is method-of-use, FDA lists it once per applicable indication ("U-code"). Each U-code carves out a specific therapeutic use that generic filers must either license or design around.

CodeDescriptionDrug
U-3593 —
U-4091 —
U-1311 — Kalydeco
U-1311 — Kalydeco
U-1905 — Kalydeco
U-3608 — Kalydeco
U-4091 —
U-3021 — Kalydeco
U-3608 — Kalydeco
U-1905 — Kalydeco
U-3021 — Kalydeco
U-3029 —
U-3145 —
U-3593 —

Patent Metadata

Patent number
US8354427
Jurisdiction
US
Classification
Method of Use
Expires
2026-07-06
Drug substance claim
No
Drug product claim
No
Assignee
Vertex Pharmaceuticals Inc
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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