US7326708 — Phosphoric acid salt of a dipeptidyl peptidase-IV inhibitor
Method of Use · Assigned to Merck and Co Inc · Expires 2026-04-11 · 0y expired
What this patent protects
This patent protects a dihydrogenphosphate salt of a dipeptidyl peptidase-IV inhibitor used for treating diabetes, obesity, and high blood pressure.
USPTO Abstract
The dihydrogenphosphate salt of 4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine is a potent inhibitor of dipeptidyl peptidase-IV and is useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as type 2 diabetes. The invention also relates to a crystalline monohydrate of the dihydrogenphosphate salt as well as a process for its preparation, pharmaceutical compositions containing this novel form and methods of use for the treatment of diabetes, obesity, and high blood pressure.
Drugs covered by this patent
FDA Patent Use Codes
When a patent is method-of-use, FDA lists it once per applicable indication ("U-code"). Each U-code carves out a specific therapeutic use that generic filers must either license or design around.
| Code | Description | Drug |
|---|---|---|
U-1188 |
— | Zocor |
U-1188 |
— | Zocor |
U-1188 |
— | Zocor |
U-1188 |
— | Zocor |
U-1188 |
— | Zocor |
U-1188 |
— | Zocor |
U-802 |
— | sitagliptin-phosphate |
U-802 |
— | sitagliptin-phosphate |
U-2214 |
— | Steglatro |
U-802 |
— | metformin-hydrochloride |
U-1227 |
— | metformin-hydrochloride |
U-1227 |
— | metformin-hydrochloride |
U-802 |
— | sitagliptin-phosphate |
U-1227 |
— | metformin-hydrochloride |
U-802 |
— | metformin-hydrochloride |
U-2214 |
— | Steglatro |
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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