US Patent

US11999744 — Crystalline forms of (S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making

Method of Use · Assigned to Blueprint Medicines Corp · Expires 2040-04-10 · 14y remaining

Vulnerability score 75/100 Vulnerable — likely target for IPR or design-around

What this patent protects

This patent protects crystalline forms of the drug Ayvakit and methods for making it, as well as methods of using it to treat certain disorders and conditions.

USPTO Abstract

Crystalline Forms of Compound (I):pharmaceutically acceptable salts thereof and solvates of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating disorders and conditions associated with oncogenic KIT and PDGFRA alterations using the same, and methods for making Compound (I) and crystalline forms thereof are also disclosed.

Drugs covered by this patent

Ayvakit (AVAPRITINIB) · Blueprint Medicines

FDA Patent Use Codes

When a patent is method-of-use, FDA lists it once per applicable indication ("U-code"). Each U-code carves out a specific therapeutic use that generic filers must either license or design around.

Code	Description	Drug
`U-3168`	—	Ayvakit
`U-3168`	—	Ayvakit
`U-3168`	—	Ayvakit
`U-3168`	—	Ayvakit

Patent Metadata

Patent number: US11999744
Jurisdiction: US
Classification: Method of Use
Expires: 2040-04-10
Drug substance claim: No
Drug product claim: No
Assignee: Blueprint Medicines Corp
Source: FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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