US Patent

US11998605 — Stabilized aqueous compositions of neuromuscular blocking agents

Formulation · Assigned to B Braun Melsungen AG · Expires 2039-07-22 · 13y remaining

Vulnerability score 55/100 Moderate — design-around opportunities exist

What this patent protects

This patent protects a stabilized aqueous composition containing Rocuronium at a concentration of 5-20 mg/mL, with D-gluconic acid or D-glucono-delta-lactone as an excipient.

USPTO Abstract

The present invention relates to an aqueous composition comprising: (i) a steroidal neuromuscular blocking agent that is a Rocuronium salt, further wherein the steroidal neuromuscular blocking agent is present at a concentration ranging from 5 mg/mL to 20 mg/mL based on the total volume of the aqueous composition; and (ii) an excipient that includes D-gluconic acid, D-glucono-delta-lactone, or a combination thereof, where the steroidal neuromuscular blocking agent and the excipient are dissolved in a solution consisting of water. Furthermore the present invention relates to a liquid pharmaceutical composition comprising or consisting of said aqueous composition and a method for producing said aqueous composition.

Drugs covered by this patent

Patent Metadata

Patent number
US11998605
Jurisdiction
US
Classification
Formulation
Expires
2039-07-22
Drug substance claim
No
Drug product claim
Yes
Assignee
B Braun Melsungen AG
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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