US11564926 — Methods of synthesizing thyroid hormone analogs and polymorphs thereof
Method of Use · Assigned to Hoffmann La Roche Inc · Expires 2033-09-17 · 7y remaining
What this patent protects
This patent protects methods of synthesizing pyridazinone compounds, including thyroid hormone analogs and their prodrugs, and their polymorphs.
USPTO Abstract
The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRβ mutation.
Drugs covered by this patent
FDA Patent Use Codes
When a patent is method-of-use, FDA lists it once per applicable indication ("U-code"). Each U-code carves out a specific therapeutic use that generic filers must either license or design around.
| Code | Description | Drug |
|---|---|---|
U-3861 |
— | resmetirom |
U-3861 |
— | resmetirom |
U-3861 |
— | resmetirom |
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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