US10631746 — Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography
Method of Use · Assigned to Novadaq Technologies ULC · Expires 2035-08-04 · 9y remaining
What this patent protects
This patent protects a method and apparatus for measuring changes in blood flow in tissue using a fluorescence agent and photoplethysmography.
USPTO Abstract
A method, an apparatus, and a kit including the apparatus and a fluorescence agent are provided for measuring a time-varying change in an amount of blood in a tissue volume, and include exciting a fluorescence agent in the blood, acquiring a time-varying light intensity signal during a pulsatile flow of the blood through the tissue volume, the pulsatile flow having a systolic and a diastolic phase resembling a conventional photoplethysmogram, and processing the acquired signal by applying a modified Beer-Lambert law to obtain a measurement of the time-varying change in the amount of blood in the tissue volume. The instantaneous molar concentration of the fluorescence agent is determined by utilizing a concentration-mediated change in a fluorescence emission spectrum of the fluorescence agent. There is further provided a fluorescence agent for use in the method.
Drugs covered by this patent
- Spy Agent Green Kit (INDOCYANINE GREEN) · Renew Pharms
FDA Patent Use Codes
When a patent is method-of-use, FDA lists it once per applicable indication ("U-code"). Each U-code carves out a specific therapeutic use that generic filers must either license or design around.
| Code | Description | Drug |
|---|---|---|
U-2815 |
— | Spy Agent Green Kit |
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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