US10292954 — Composition and method for muscle repair and regeneration
Method of Use · Assigned to Thomas Jefferson University · Expires 2031-08-31 · 5y remaining
What this patent protects
This patent protects methods for muscle repair or regeneration using RAR agonists or treated stem cells, and compositions of treated stem cells for this purpose.
USPTO Abstract
The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RARγ agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.
Drugs covered by this patent
- Sohonos (PALOVAROTENE) · Ipsen
FDA Patent Use Codes
When a patent is method-of-use, FDA lists it once per applicable indication ("U-code"). Each U-code carves out a specific therapeutic use that generic filers must either license or design around.
| Code | Description | Drug |
|---|---|---|
U-3676 |
— | Sohonos |
U-3676 |
— | Sohonos |
U-3676 |
— | Sohonos |
U-3676 |
— | Sohonos |
U-3676 |
— | Sohonos |
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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