US10265281 — Treatment or prevention of cardiovascular events via the administration of a colchicine derivative

USPTO Abstract

A method for the treatment or prevention of a cardiovascular event in a subject with atherosclerotic vascular disease comprising the step of: b) administering a therapeutically effective amount of a compound of formula (I), a known colchicine derivative and/or a salt thereof wherein: R 1 , R 2 , R 3 , R 4 , R 9 , R 10 , R 11 and R 12 independently represent hydrogen, C 1-4 alkyl, C 2-4 alkenyl, C 3-6 cycloalkyl, halogen, C 1-4 haloalkyl, nitro, amino, C 2-4 acylamino, C 1-4 alkyl or dialkylamino, hydroxyl, C 1-4 alkoxy, C 1-4 alkylthio, a group of the formula —SO 2 N(R x ) 2 or SO 2 R x where R x is C 1-4 alkyl, C 1-4 acyloxy, or optionally substituted phenyl, optionally substituted phenoxy; R 7 and R 8 independently represent hydrogen, C 1-4 alkyl or C 1-4 acyl; and R 5 ′, R 5 ″, R 6 ′ and R 6 ″ independently represent hydrogen, C 1-4 alkyl, C 2-4 alkenyl, C 3-6 cycloalkyl, halogen, C 1-4 haloalkyl, nitro, amino, C 2-4 acylamino, hydroxyl, C 1-4 alkoxy or C 1-4 alkylthio a group of the formula —SO 2 N(R x ) 2 or SO 2 R x where R x is C 1-4 alkyl, C 1-4 acyloxy, or optionally substituted phenyl.