US Patent

US10028995 — Angiotensin II alone or in combination for the treatment of hypotension

Method of Use · Assigned to George Washington University · Expires 2034-12-18 · 9y remaining

Vulnerability score 45/100 Strong — defensible against typical IPR challenges

What this patent protects

This patent protects a method of treating high output shock in a subject by administering a dose of angiotensin II to raise blood pressure and reduce the required dose of a catecholamine.

USPTO Abstract

The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.

Drugs covered by this patent

FDA Patent Use Codes

When a patent is method-of-use, FDA lists it once per applicable indication ("U-code"). Each U-code carves out a specific therapeutic use that generic filers must either license or design around.

CodeDescriptionDrug
U-2338 — angiotensin-ii-acetate
U-2338 — angiotensin-ii-acetate
U-2338 — angiotensin-ii-acetate

Patent Metadata

Patent number
US10028995
Jurisdiction
US
Classification
Method of Use
Expires
2034-12-18
Drug substance claim
No
Drug product claim
No
Assignee
George Washington University
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

Track this patent

Get a daily-checked alert when vulnerability score, expiry, classification, or assignee changes. Email, Slack, or Teams delivery. Pro: 50 watches, Free: 3.