GB9910577D0 — Chemical compounds

USPTO Abstract

1. A compound of formula (I) <CHEM> or a pharmaceutically acceptable salt thereof. wherein: n is 0-1; X and Y are independently selected from -NH-, -O-, -S-, or -NR<8>- where R<8> is alkyl of 1-6 carbon atoms and X may additionally comprise a CH2 group; R<7> is a group (CH2)mR<9> where m is 0,or an integer of from 1-3 and R<9> is a substituted aryl group, an optionally substituted cycloalkyl ring of up to 10 carbon atoms, or an optionally substituted heterocyclic ring or an N-oxide of any nitrogen containing ring; R<6> is a divalent cycloalkyl of 3 to 7 carbon atoms, which may be optionally further substituted with one or more alkyl of 1 to 6 carbon atom groups; or is a divalent pyridinyl, pyimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally further substituted with one or more specified groups; R1, R2, R3 and R4 are each independently selected from hydrogen or various specified organic groups. <??>Compounds are useful as pharmaceuticals for the inhibition of MEK activity.