GB935639A — Pharmaceutical compositions comprising drug/resin adsorbates

USPTO Abstract

Drug/resin adsorbates are prepared by contacting an aqueous solution of a salt (e.g. the phosphate) of amprotropine with a nuclear sulphonic acid cation-exchange resin, e.g. a polymerized vinyl benzene containing nuclear sulphonic acid groups of the type disclosed in Specification 577,707 in the hydrogen or alkali metal cycle.ALSO:Pharmaceutical compositions comprise particles of a nuclear sulphonic acid cation-exchange resin in which at least some of the cations present are those of amprotropine, the particles being coated with caster wax. The coated particles may be prepared by suspending the active compound in molten caster wax and spray chilling the suspension by conventional means, e.g. atomizing spray nozzles, bifluid spray nozzles, centrifugal atomizing wheels or nozzles and are suitable for slow oral ingestion, e.g. by chewing, sucking or sipping. They may be incorporated into conventional pharmaceutical forms, e.g. tablets alone and together with antacids, e.g. aluminium hydroxide, aluminium silicate, dihydroxy aluminium acetate; antiallergenics, e.g. phenindamine tartrate, sedatives, e.g. phenobarbitol and methyprylon; decongestants, e.g. phenylephrine, hydrochloride; acetyl salicylic acid, caffeine, acetophenetidin and 1,5 - dimethyl - 4 - isopropyl - 2-phenylpyrazolone-(3). Specification 577,707 is referred to.