GB903866A — Therapeutic preparations containing 7-substituted theophylline derivatives

USPTO Abstract

A therapeutic preparation for the treatment of asthma comprises (a) a purine component having a musculotropic action which is a water-soluble 7-substituted thiophylline derivative and (b) an adrenergic component which is the hydrochloride of 1-(3,4-dihydroxyphenyl)-2-methyl-amino-1-propanol. Specified theophylline derivatives are 7-beta-hydroxyethyl theophylline, 7-beta-gamma dihydroxypropyl theophylline and a salt of theophylline-7-ethanoic acid. The preparation may be used orally, e.g. as a tablet, parenterally, e.g. in aqueous solution, as an aerosol or as a suppository. Optional ingredients are (a) barbiturate drugs such as butobarbital and butylethyl-malonylurea, (b) antioxidant or reducing agent, e.g. sodium bisulphite or sodium formaldehyde sulphoxylate, (c) theophylline, theophylline ethylenediamine and caffeine.