GB901107A — Therapeutic composition and method of preparing same

USPTO Abstract

A therapeutic composition comprises a solution of at least one of the following antibiotic salts: magnesium, calcium or aluminium tetracycline salt or a magnesium, calcium aluminium or zinc oxytetracycline salt in one or more of the following polyhydric aliphatic alcohol solvents: glycerine, polyethylene glycol or propylene glycol, the molar ratio of metal to antibiotic being about 3 : 1 in the case of tetracycline and from 1 : 3 to 3 : 1 in the case of oxytetracycline and the pH of the solution being from 7 to 10. The metal tetracycline or oxtetracycline salts may be prepared in situ and mixed salts of two metals may be employed e.g. calcium, magnesium oxytetracycline or magnesium zinc oxtetracycline. A non-toxic alkanol, e.g. sorbitol or ethanol may be added in an amount of up to 20% of the solutions. The compositions are administered (a) intramuscularly or when diluted with water intravenously, (b) as otic or veterinary opthalmic solutions and in humans as otic solutions, mouthwashes or disinfectants, or (c) as salves or suppositories, using as a solvent a high molecular weight polyethylene glycol, e.g. the carbowaxes. The compositions may contain additionally (a) antibiotics, e.g. streptomycin, polymixin B sulphate, carbomycin or oleandomycin, (b) steroid hormones, e.g. prednisolone, cortisone or hydrocortisone, (c) buffering agents and other stabilizers, e.g. ascorbic acid, triethanolamine, diethanolamine, sodium phosphite, sodium bisulphite and sodium formaldehyde sulphorylate, (d) colouring and flavouring agents, e.g. sodium cyclamate, sodium saccharin, sodium ascorbate, menthol, sodium sucaryl, saccharin, sulphosalicylic acid and benzocain.