GB8803963D0 — Therapeutic agents

USPTO Abstract

Compounds of the formula:- <CHEM> wherein R is phenyl or phenyl substituted by nitro, halo, C1-C4 alkyl, C1-C4 alkoxy, aryl(C1-C4)alkoxy, fluoro(C1-C4)alkoxy, C1-C4 alkylthio, C1-C4 alkylsulphonyl, hydroxy, trifluoromethyl or cyano; R<1> and R<2> are H or C1-C6 alkyl, or the two groups form a pyrrolidinyl, piperidino, morpholino, piperazinyl, N-(C1-C4 alkyl)piperazinyl or N-(C2-C4 alkanoyl)piperazinyl group; or R<2> is H or C1-C4 alkyl and R<1> is C3-C7 cycloalkyl, aryl, indanyl, or heteroaryl, or a C1-C4 alkyl group substituted by C3-C7 cycloalkyl, C1-C4 alkoxycarbonyl, aryl or heteroaryl; R<3> is OH, C1-C6 alkoxy, aryl(C1-C4 alkoxy), or NR<4>R<5> wherein each of R<4> and R<5> is independently H or C1-C6 alkyl, or the two groups form a pyrrolidinyl, piperidino, morpholino, piperazinyl, or N-(C1-C4 alkyl)piperazinyl group; Y is an alkylene group of from 2 to 8 carbon atoms and X is 1,2,4-triazol-3-yl, 1,2,4-triazol-4-yl or triazolo[2,3-a]pyrid-2-yl optionally substituted by C1-C4 alkyl or phenyl; are antagonists of PAF and are useful in the treatment of allergic, inflammatory and hypersecretory conditions.