GB873526A — Fluid compositions comprising (acetyl-salicylic acid)-anhydride

USPTO Abstract

A stable, fluid composition for oral use comprises (acetylsalicylic acid)-anhydride and a liquid carrier which may be glycerine, propylene glycol, a liquid polyalkylene glycol, a vegetable oil, e.g. coconut, cottonseed or sesame oils, 2,2-dimethyl-4-oxymethyl-1,3-dioxolane, N,N-dimethyl acetamide (preferred for solutions) or mixtures thereof which are miscible with each other and compatible with other ingredients. Anhydrous ethanol may also be present when compatible, e.g. with glycerine or propylene glycol. The water content of the vehicle should not exceed 5% by weight and preferably should not be more than 1%. Additional active ingredients, for example, acetophenetidin, caffeine, codeine, salicylamide, N - acetyl - p - aminophenol, cortisone, hydrocortisone or its derivatives, tranquilizers, sedatives, antihistaminics, anti-ussive agents, antibiotics and vitamins, especially ascorbic, pantothenic and p-aminobenzoic acids, may also be present. Other ingredients, for example, sweetening, suspending, demulcent, flavouring and surface-active agents, may also be added. The anhydride and other ingredients may be in particles of reduced size produced, for example, by milling to give particles of about 10 to 100 microns in size or by jet-pulverizing e.g. air-micronizing to give particles of under 10 microns. For suspensions, for which glycerine is the preferred vehicle, uniformity of the product may be assured, e.g. by passage through a colloid mill or homogenizing equipment. Examples given are suspensions in glycerine, glycerine and ethanol, polyethylene glycol, propylene glycol, coconut oil and cottonseed oil comprising also acetophenetidin, caffeine, codeine, hydrocortisone, phenobarbitol, benactyzine, tetracycline and b -ortho-methoxyphenylisopropyl methylamine and of a solution in N,N-dimethylacetamide.