GB864100A — Therapeutic pencillin compositions and the preparation thereof

USPTO Abstract

Injectable suspensions comprise an aqueous suspension of a water-insoluble salt of penicillin and 0.5 to 10% of choline or a water-soluble derivative thereof. About 3 to 10% of urea or a derivative, 1 to 5% of a parenterally acceptable suspending agent and about 0.25 to 5% (based on the weight of the penicillin salt) of a parenterally acceptable buffer. Preservatives may also be added. The penicillin salt may be that with procaine, dibenzylethylenediamine, N - benzyl - N1 - (3 - ethoxy - 4 - hydroxy)-benzyl ethylenediamine, 2-chloroprocaine and N,N1 - di - (4 - methoxybenzyl) ethylene diamine. The choline derivative may be the chloride, dihydrogen tartrate, dihydrogen citrate or chloride carbamate. Examples of urea derivatives are thiocarbamide, carbamyl chloride, urea nitrate, thiomethane, lower (up to four carbon atoms) alkyl carbamates.