GB8327256D0 — Steroid derivatives

USPTO Abstract

A steroid derivative of the formula:wherein ST is a 7a-linked steroid nucleus of the general formula:wherein the double bond(s) carbon atoms 6 and 7 and/or carbon atoms 8 and 9 are optional;wherein the aromatic ring A may optionally bear one or two halogen or alkyl substituents;wherein R<sup>3</sup> is hydrogen, alkyl, or acyl;wherein R<sup>16</sup> is hydrogen, alkyl or hydroxy;wherein either R<sup>17</sup> is hydroxy or acyloxy and R<sup>27</sup> is hydrogen, alkyl, alkenyl or alkynyl, or R<sup>17</sup> and R<sup>27</sup> together form oxo (=0);wherein R<sup>18</sup> is alkyl;wherein A is alkylene, alkenylene or alkynylene optionally fluorinated and optionally interrupted by -0-, -S-, -SO-, -S0<sub>2</sub>-, -CO-, -NR-, -NRCO-, -CONR-, -COO-, -OCO- or phenylene, wherein R is hydrogen or alkyl;wherein R<sup>1</sup> is hydrogen, alkyl, alkenyl, cycloalkyl, halogenoalkyl, carboxyalkyl, alkoxycarbonylalkyl, aryl, arylalkyl, or dialkylaminoalkyl, or R<sup>1</sup> is joined to R<sup>2</sup> as defined below; and wherein X is -CONR<sup>2</sup>-, -CSNR<sup>2-</sup>, -NR<sup>12</sup>CO-, -NR<sup>12</sup>CS-, N<sub>R</sub>2<sub>2</sub> -NR<sup>12</sup>CONR<sup>2</sup>-, NR<sup>12</sup>-C-NR<sup>2</sup>-, -SO<sub>2</sub>NR<sub>2</sub>-, or-CO-; or, when R<sup>1</sup> is not hydrogen, is -O-, -NR<sup>2</sup>-, -(NO)R<sup>2</sup>-, -(PO)R<sup>2</sup>-, -NR<sup>12</sup>COO-; -NR<sup>12</sup>SO<sub>2</sub>-, -S-, -SO- or -S0<sub>2</sub>-;wherein R<sup>2</sup> is hydrogen or alkyl or R<sup>1</sup> annd R<sup>2</sup> together form alkylene or halogenoalkylene;wherein R<sup>12</sup> is hydrogen or alkyl and wherein R<sup>22</sup> is hydrogen, cyano or nitro;or a salt thereof when appropriate.