GB751767A — Improvements in antitussive compositions

USPTO Abstract

An antitussive composition which may take the form of powders, tablets, capsules, syrups, or elixirs, comprises a potent analgesic and as an analgesic antagonist, N-allylnormorphine, N-allylnorcodeine, N-allyldihydronormorphinone, N-allyldihydronorcodeinone, or a mixture thereof, which may be present from 0,1 to 5,0 parts for each part by weight of the analgesic. Examples of the analgesic are codeine, morphine, dihydromorphine, dihydrocodeine, dihydromorphinone, dihydrocodeinone, diacetylmorphine, d, l-isomethadone, l-isomethadone, d, l-methadone, l-methadone, 3-hydroxy-N-methylmorphinan 6-methyl-D 6-desoxymorphine, ethylmorphine, N-methyl-4-phenyl-4-carbethoxypiperidine hydrochloride and hydroxydihydrocodeinone. The analgesic and antagonist may be present as the free base or as the acid addition salt e.g. sulphate, phosphate, citrate, hydrochloride or hydrobromide. Diluents which are mentioned are lactose, sucrose, starch, magnesium stearate, potassium guaiacolsulphonate, glycerine, ethyl alcohol, and simple syrup.