GB335965A — Process for the manufacture of complex iron compounds

USPTO Abstract

335,965. Carpmael, A., (I. G. Farbenindustrie Akt.-Ges.). June 5, 1929. Complex iron compounds of aliphatic hydroxycarboxylic acids are prepared by treating a polyhydroxy mono- or poly-carboxylic acid of the pentane or hexane series or a salt thereof with iron or an iron compound, the reaction mixture being simultaneously or subsequently neutralized with a basic substance. Acids specified comprise pentonic acids (tetrahydroxy-monocarboxylic acids) such as hexane-tetrolic acid (2-methylpentane tetrolic acid), hexonic acids such as gluconic acid, trihydroxyglutaric acids, glucuronic acid, and tetrahydroxyadipic acids such as saccharic and mucic acids and their isomers. As basic substance may be used the alkalies and also nitrogenous bases such as ammonia, diethylamine, diethylaminoethanol, choline and quinine. The iron compound may comprise ferrous or ferric hydroxide or a corresponding water-soluble salt such as ferric acetate or ferric and ferrous chlorides. The preparation may be effected by dissolving iron in the acid and then neutralizing, or by mixing an aqueous solution of the acid or its salt with an aqueous solution of an iron salt and neutralizing, or by treating the acid or its salt with ferrous or ferric hydroxide and subsequently neutralizing. The iron may be present in the product in the proportion of one atom or iron to one molecule of acid or in such other proportions as 1 : 2, 2 : 1, and 3 : 1. The products, which can be isolated by precipitation or evaporation, are readily water-soluble and are useful therapeutically. Examples are given of the preparation of sodium ferrous and ferric gluconates, potassium-sodium ferrous and ferric saccharates, quinine potassium ferrous saccharate, and sodium iron mucate. Specification 326,231 is referred to.