GB2631129A — A powder composition for oral suspension of proton pump inhibitors and the method of preparing the same

USPTO Abstract

Powder composition for oral suspension comprising a two phase powder mixture, where the first phase is in powder form comprising a Proton Pump Inhibitor (e.g. omeprazole) or pharmaceutically acceptable salts thereof in an amount of 0.01-7.5 % by weight, at least one diluent (e.g. mannitol), a first buffering agent (e.g. sodium hydrogen carbonate), a binding agent (e.g. xanthan gum), and the second phase is in powder form comprising a second buffering agent, a viscosity enhancer (e.g. sodium alginate) in the range 0.0010 %w/w to 2.0 wt.%, at least one diluent; at least one preservative (e.g. sodium benzoate, sodium methyl para hydroxy benzoate), a diluent, and an excipient (e.g. a flavour). Preferably, the second buffering agent is a carbonate or hydrogen carbonate. Preferably, the D50 of the omeprazole, if present, is 1.5-5.5 microns. The composition may be used in the treatment of erosive oesophagitis, gastroesophageal reflux, gastric ulcers etc.