GB2622822A — A rapidly disintegrating tablet of rosuvastatin and its process of preparation

USPTO Abstract

A rapidly disintegrating tablet is disclosed that can disintegrate in the buccal cavity upon contact with saliva in less than 1 minute, preferably in less than 40 seconds, the tablet comprising rosuvastatin or pharmaceutically acceptable salts thereof, as well as a combination of excipients that include at least one disintegrating agent and at least one diluent agent. The preferred embodiment comprises 2-7% rosuvastatin calcium, 1-7.5% croscarmellose sodium, 15-85% microcrystalline cellulose and mannitol, a lubricant such as magnesium stearate, a sweetener such as sucralose, and a flavouring agent such as orange. The present formulation of rosuvastatin has improved disintegration and dissolution properties that make it suitable for oral administration.