GB2618810A — Pharmaceutical composition for sublingual administration of clonidine

USPTO Abstract

A solid pharmaceutical composition suitable for sublingual administration comprising clonidine or pharmaceutically acceptable salts thereof, at least one disintegrant and at least one diluent. Clonidine or its pharmaceutically acceptable salt may be present in range of 0.005-0.2 %w/w. The disintegrant may be selected from alginic acid, carbon dioxide, carboxymethylcellulose calcium, carboxymethylcellulose sodium, croscarmellose sodium, guar gum, methylcellulose, polacrilin potassium, poloxamer, sodium alginate, and sodium starch glycolate; and may be present in the range of 0.5-10 %w/w. The diluent may be selected from: mannitol, microcrystalline cellulose, dextrates, dextrose, fructose, sorbitol, starch, pregelatinized starch, sucrose, xylitol, maltose, maltodextrin, maltitol or mixtures thereof; and may be present in the range of 30-99 %w/w. The composition may further comprise sweeteners, flavouring agents, binder, glidants, and lubricants. The composition may be for treatment of all grades of essential/secondary hypertension, prophylactic management of migraine or recurrent vascular headache and vasomotor conditions of the menopause.