GB2597302A — Use of cannabidiol in the treatment of seizures associated with stroke or brain haemorrhage

USPTO Abstract

The use of cannabidiol (CBD) for the treatment of seizures associated with stroke or brain haemorrhage. The types of seizures may include tonic, tonic-clonic, atonic, myoclonic, absence, focal seizures without impairment, focal seizures with impairment and focal seizures with secondary generalisation. The CBD preparation may comprise 95% (w/w) CBD and not more than 0.15% (w/w) tetrahydrocannabinol (THC). Preferably the CBD preparation comprises greater than or equal to 98% (w/w) CBD and less than or equal to 2% (w/w) other cannabinoids, which may comprise THC, cannabidiol-C1 (CBC-C1), cannabidivarin (CBDV), and cannabidiol-C4 (CBD-C4), where the THC may be a mixture of trans-THC and cis-THC. The CBD preparation may be used in combination with one or more concomitant anti-epileptic drugs (AEDs) such as valproic acid, diazepam, levetiracetam, clobazam, topiramate, lamotrigine, lacosamide, phenytoin, rufinamide, zonisamide, and gabapentin. The CBD in the CBD preparation may be synthetic or isolated from cannabis plant material. Preferably the dose of CBD is between 5 mg/kg/day to 50 mg/kg/day.