GB2584140A — Use of cannabidiol in the treatment of epileptic spasms

USPTO Abstract

The present invention relates to the use of cannabidiol (CBD) for the treatment of epileptic spasms. In particular the epileptic spasms that are treated are associated with Tuberous Sclerosis Complex (TSC). In a further embodiment the epileptic spasm is treated with CBD in combination with clobazam. Preferably the CBD used is in the form of a botanically derived purified CBD which comprises greater than or equal to 98% (w/w) CBD and less than or equal to 2% (w/w) of other cannabinoids. The other cannabinoids present are THC at a concentration of less than or equal to 0.1% (w/w); CBD-C1 at a concentration of less than or equal to 0.15% (w/w); CBDV at a concentration of less than or equal to 0.8% (w/w); and CBD-C4 at a concentration of less than or equal to 0.4% (w/w). The botanically derived purified CBD preferably also comprises a mixture of both trans-THC and cis-THC. Alternatively, a synthetically produced CBD is used. Where the CBD is given concomitantly with one or more other anti-epileptic drugs (AED) including clobazam, the CBD may be formulated for administration separately, sequentially or simultaneously with one or more AED or the combination may be provided in a single dosage form.