GB2548542A — Compounds

USPTO Abstract

Imidazo[4,5]pyrrolo[1,2-a]pyridin-5-yl compounds of formula (I) where A is a 6-membered heteroaryl group which may be optionally substituted as herein defined; Z is a substituent as herein defined; Y is a 5- or 6-membered carbocyclic or heterocyclic group which may be optionally substituted as herein defined; W is a bond or a substituent as herein defined; and R1 and R2 are each independently substituents as herein defined. The compounds of formula (I) are useful as indoleamine-2,3-dioxygenase (IDO) and/or tryptophan-2,3-dioxygenase (TDO) modulators (e.g. IDO and TDO inhibitors) and are preferably useful in treating indoleamine-2,3-dioxygenase (IDO) and/or tryptophan-2,3-dioxygenase (TDO) mediated diseases, such as IDO and/or TDO immunosuppression; treating conditions benefiting from inhibition of enzymatic activity of the IDO and/or TDO enzyme; enhancing the effectiveness of anti-cancer therapy; treating tumor specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease.