GB2546128A — Pharamaceutical compositions comprising hexaminolevulinic acid and methods of using the same

USPTO Abstract

A pharmaceutical composition comprising: (a) an active ingredient selected from the group consisting of hexaminolevulinate, a precursor thereof, a derivative thereof, and a pharmaceutically acceptable salt thereof; (b) optionally at least one triglyceride; and (c) at least one emulsifier, is outlined. Preferably the composition may further comprise one or more of (i) at least one mucoadhesive agent; (ii) at least one surface penetration agent; (iii) at least one chelating agent; and (iv) citric acid. Preferably the composition further comprises at least one coating selected from the group consisting of triethyl citrate, talc, a copolymer of methacrylic acid and methyl methacrylate, and a copolymer of methacrylic acid and ethyl acrylate. A pharmaceutical composition comprising hexaminolevulinate, or a pharmaceutically acceptable salt thereof; (b) a diluent; and (c) a lubricant, wherein the composition is enterically coated with at least one coating is also provided. The compositions are useful in conducting photodynamic diagnosis (PDD) or photodynamic therapy (PDT), in particular to diagnose or treat a condition in the lower gastrointestimal tract of a subject, such as, for example, colorectal cancer.